Natural Products, Chemical Compounds, and Gene Targets for Weight Loss: Discoveries from Genetic Interactions PharmTao.com

ISBN:

Published: March 8th 2009

Kindle Edition

18 pages


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Natural Products, Chemical Compounds, and Gene Targets for Weight Loss: Discoveries from Genetic Interactions  by  PharmTao.com

Natural Products, Chemical Compounds, and Gene Targets for Weight Loss: Discoveries from Genetic Interactions by PharmTao.com
March 8th 2009 | Kindle Edition | PDF, EPUB, FB2, DjVu, audiobook, mp3, RTF | 18 pages | ISBN: | 9.28 Mb

Body weight is decided by the balance between food intake and energy expenditure. Some genes have been found to be important signal molecules in the cells and play crucial roles in the central regulation of food intake, feeding behavior, and energy homeostasis. These genes are potential targets and biomarkers for the treatment of obesity and associated diseases such as diabetes and cardiovascular diseases. Variations in these genes may also be important for developing personalized medicines for people in different groups of age, gender, and race, such as childhood obesity.Many natural products, such as extracts and compounds from fruits and herbs, have weight loss effects and can protect against high-fat-diet induced obesity.

They are potential therapeutics for anti-obesity and healing obesity-related diseases. These natural products and compounds can be used in food ingredients, diet therapy, or drug components for the treatment of obesity. Recent scientific studies have elucidated the molecular mechanisms of these products.

The weight loss effects of these products may be mediated through adjusting genes involved in energy homeostasis. With the identification of potential gene targets for anti-obesity, understanding of the interactions between different products and obesity-related genes would enable the discovery of new and safe therapeutic agents for the serious health problems.Excerpts:“They examined the influence of … supplementation on cell sizes and lipid metabolism in adipose tissues….

may have more benefits than the anti-diabetic drug, as it can inhibit the visceral fat accumulation…. In summary, recent studies have demonstrated that … has a great potential not only for the treatment of diabetes, but also for anti-obesity and weight loss.”“A recent study found that … supplementation significantly reduced body weight gain in rats fed with a high-fat diet.

The supplement lowered visceral fat-pad weights, blood lipid levels, and blood insulin and leptin levels. … Researchers studied the molecular mechanisms of the anti-obesity effect of ... They observed that the … supplement could reverse the decreased expression levels of certain genes caused by the high-fat diet.

… In conclusion, … extract has an anti-obesity effect in models with high-fat-diet-induced obesity.”“… treatment reduced body weight, subcutaneous adipose tissue weight, and the size of subcutaneous adipocytes. The herbal supplement suppressed fat accumulation, and inhibited pancreatic lipase activity. In addition, … significantly decreased plasma total cholesterol (TC) and triglycerol (TG) concentrations. … is a potential agent that can be used in food ingredients, diet therapy, or drug components for the treatment of obesity.”“the compound … can be a potential agent to prevent the development of diet-induced obesity.

It may have such effects through inhibiting adipocyte differentiation, … and its interactions with the insulin signaling pathway.”“… may inhibit fat accumulation in subjects fed with a high-fat diet. Such anti-obesity effect may be related with increased expression of the protein … in the skeletal muscle.… This compound may be also beneficial for the treatment of atherosclerosis and diabetes mellitus.”“It has also been suggested a potential target for future drugs for anti-obesity treatment.

… is expressed mostly in the limbic and sensory systems. It may be involved in motivation, emotion, autonomic functions, and sensory information processing. Subjects with …-deficiency had higher body weight, body fat mass … and had lower energy expenditure.



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